CIGARETTE SMOKE EXTRACT INDUCES PLACENTAL GROWTH FACTOR RELEASE FROM HUMAN BRONCHIAL EPITHELIAL CELLS VIA ROS/MAPK(ERK-1/2)/EGR-1 AXIS

Cigarette smoke extract induces placental growth factor release from human bronchial epithelial cells via ROS/MAPK(ERK-1/2)/Egr-1 axis

Dong Wu,1,* Yalian Yuan,1,* Zhixiu Lin,2,* Tianwen Lai,1 Min Chen,1 Wen Li,1 Quanchao Lv,1 Binfan Yuan,1 Dongmin Li,1 Bin Wu1 1Department of Respiratory, Institute of Respiratory Diseases, 2Department of Pharmacy, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, People’s Republic of China *These authors contributed equally

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Longevity of hybrid immunity against SARS-CoV-2 in adults vaccinated with an adenovirus-based COVID-19 vaccine

Abstract Background Hybrid immunity provides better protection against COVID-19 than vaccination or prior natural infection alone.It induces high magnitude and broadly cross-reactive neutralising anti-Spike IgG antibodies.However, it is not clear how long these potent antibodies last, especially in the context of adenovirus-based COVID-19 vaccines.

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